Please use this identifier to cite or link to this item:
|Title:||Clinical and histological characterization of oral pemphigus lesions in patients with skin diseases: a cross sectional study from Sudan|
|Authors:||Suliman, Nada M.;Åstrøm, Anne Nordrehaug;Ali, Raouf Wahab;Salman, Hussein;Johannessen, Anne Christine|
|Keywords:||Oral pemphigus;Skin disease;Histology;Immunohistochemistry;Sudan|
|Description:||<p>Background: Pemphigus is a rare group of life-threatening mucocutaneous autoimmune blistering diseases.
Frequently, oral lesions precede the cutaneous ones. This study aimed to describe clinical and histological features
of oral pemphigus lesions in patients aged 18 years and above, attending outpatient’s facility of Khartoum Teaching
Hospital - Dermatology Clinic, Sudan. In addition, the study aimed to assess the diagnostic significance of routine
histolopathology along with immunohistochemical (IHC) examination of formalin-fixed, paraffin-embedded biopsy
specimens in patients with oral pemphigus.</p><p>Methods: A cross-sectional hospital-based study was conducted from October 2008 to January 2009. A total of 588
patients with confirmed disease diagnosis completed an oral examination and a personal interview. Clinical
evaluations supported with histopathology were the methods of diagnosis. IHC was used to confirm the diagnosis.
Location, size, and pain of oral lesions were used to measure the oral disease activity.</p><p>Results: Twenty-one patients were diagnosed with pemphigus vulgaris (PV), 19 of them (mean age: 43.0; range:
20–72 yrs) presented with oral manifestations. Pemphigus foliaceus was diagnosed in one patient. In PV, female:
male ratio was 1.1:1.0. Buccal mucosa was the most commonly affected site. Exclusive oral lesions were detected in
14.2% (3/21). In patients who experienced both skin and oral lesion during their life time, 50.0% (9/18) had oral
mucosa as the initial site of involvement, 33.3% (6/18) had skin as the primary site, and simultaneous involvement
of both skin and oral mucosa was reported by 5.5% (1/18). Two patients did not provide information regarding the
initial site of involvement. Oral lesion activity score was higher in those who reported to live outside Khartoum
state, were outdoor workers, had lower education and belonged to Central and Western tribes compared with their
counterparts. Histologically, all tissues except one had suprabasal cleft and acantholytic cells. IHC revealed IgG and
C3 intercellularly in the epithelium.</p><p>Conclusions: PV was the predominating subtype of pemphigus in this study. The majority of patients with PV
presented with oral lesions. Clinical and histological pictures of oral PV are in good agreement with the literature.
IHC confirmed all diagnoses of PV.</p>|
|Other Identifiers:||BMC Oral Health 13:66|
|Appears in Collections:||Faculty of Medicine and Dentistry|
Files in This Item:
Click on the URI links for accessing contents.
Items in HannanDL are protected by copyright, with all rights reserved, unless otherwise indicated.