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|Title:||Interstitial fluid: the overlooked component of the tumor microenvironment?|
|Authors:||Wiig, Helge;Tenstad, Olav;Iversen, Per Ole;Kalluri, Raghu;Bjerkvig, Rolf|
|Description:||<p>Background: The interstitium, situated between the blood and lymph vessels and the cells, consists of a solid or
matrix phase and a fluid phase, together constituting the tissue microenvironment. Here we focus on the
interstitial fluid phase of tumors, i.e., the fluid bathing the tumor and stromal cells. Novel knowledge on this
compartment may provide important insight into how tumors develop and how they respond to therapy.</p><p>Results: We discuss available techniques for interstitial fluid isolation and implications of recent findings with
respect to transcapillary fluid balance and uptake of macromolecular therapeutic agents. By the development of
new methods it is emerging that local gradients exist in signaling substances from neoplastic tissue to plasma.
Such gradients may provide new insight into the biology of tumors and mechanistic aspects linked to therapy. The
emergence of sensitive proteomic technologies has made the interstitial fluid compartment in general and that of
tumors in particular a highly valuable source for tissue-specific proteins that may serve as biomarker candidates.
Potential biomarkers will appear locally at high concentrations in the tissue of interest and will eventually appear in
the plasma, where they are diluted.</p><p>Conclusions: Access to fluid that reliably reflects the local microenvironment enables us to identify substances that
can be used in early detection and monitoring of disease.</p>|
|Other Identifiers:||Fibrogenesis & Tissue Repair 3(1):12|
|Appears in Collections:||Faculty of Medicine and Dentistry|
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